| RESVERATROL: Multiple studies indicate that this | | | | activating compounds, of which Resveratrol in |
| potent anti-oxidant found in red wine has a positive | | | | certainly a front runner. |
| effect on aging, cardio-vascular health, and Type II | | | | "We found SIRT1 improves insulin sensitivity, |
| Diabetes | | | | especially under insulin-resistant conditions," Zhai said. |
| Below is an explanation of the effects of | | | | "Furthermore, we found that Resveratrol, at a very |
| RESEVERATROL in general, but in particular as it | | | | low dose compared with many previous studies, |
| applies to Type II Diabetes. | | | | improves insulin sensitivity via SIRT1." Previously, he |
| Studies and research are cited which indicate that this | | | | noted, the effects of Resveratrol seen in mice had |
| powerful anti-oxidant has beneficial effects on Type | | | | implied that humans might need to drink about 120 |
| II Diabetes, insulin sensitivity, cardio-vascular health, | | | | liters of red wine each day to get enough |
| as well as aging. | | | | Resveratrol to enjoy the same benefit. "According to |
| Free radicals that we're exposed to every day-in | | | | our findings, people might need to drink about three |
| sunlight, pollution, chemicals in our food, water, and | | | | liters of red wine each day to get sufficient |
| more-are one of the root causes of aging and | | | | Resveratrol--about 15 mg--for its biological effects. |
| disease! Many of the natural metabolic processes in | | | | But due to the side effects of alcohol ingestion, it is |
| our own bodies generate harmful free radicals. Free | | | | recommended that a liquid form of Resveratrol in a |
| radicals are the natural by-product of normal cell | | | | concentrated form would be the better alternative. " |
| metabolism and can be thought of like "smoke" | | | | The researchers include Cheng Sun, Fang Zhang, |
| produced by the cells in your body, not unlike the | | | | Xinjian Ge, Tingting Yan, Xingmiao Chen, Xianglin Shi, |
| toxic smoke produced by your backyard grill. Within | | | | and Qiwei Zhai of Institute for Nutritional Sciences, |
| the body, free radicals are molecules that need | | | | Shanghai Institutes for Biological Sciences, Chinese |
| additional oxygen. Free radicals can attack any cell in | | | | Academy of Sciences, Graduate School of the |
| the body looking for oxygen, since most cells contain | | | | Chinese Academy of Sciences in Shanghai. |
| mitochondria, the respiration centers for cells. Free | | | | Resveratrol shows promise as diabetes treatment |
| radicals have a propensity for highly vascularized | | | | October 9, 2008 - 6:59am ET Scientists have unveiled |
| tissues in the body such as the internal organs, the | | | | yet another study on the potential of Resveratrol. |
| eyes, the cardio-vascular system, blood vessels, and | | | | The chemical, which is found in red wine as well as a |
| capillary-rich extremities. When free radicals do attack | | | | variety of plants, has been linked with improved |
| cells, the cells become compromised, which leads to | | | | sensitivity to insulin in mouse models, adding another |
| cell death. Extensive cell death results in tissue | | | | possible therapeutic effect for an ingredient already |
| damage, pre-mature aging, and even organ failure. | | | | associated with longevity and DNA repair. Resveratrol |
| Our main defense against free radical damage is | | | | activates the SIRT1 enzyme, and researchers at the |
| anti-oxidants obtained through our diet. Anti-oxidants | | | | University of Florida say that could make it a |
| are only found in plants, particularly the darkly | | | | candidate for treating diabetes. Researchers at U of |
| pigmented fruits and vegetables. There are a | | | | FL have confirmed earlier reports that SIRT1 levels |
| multitude of studies which prove that individuals who | | | | are reduced in insulin-resistant cells and tissues and |
| consume diets which are rich in anti-oxidants | | | | that treatments that block the enzyme's function |
| experience decreased signs of aging and disease. For | | | | lead to insulin resistance. Furthermore, increased |
| many years, supplementation with anti-oxidants has | | | | SIRT1 activity improved insulin sensitivity. Similarly, |
| been an accepted and necessary course of | | | | Resveratrol--at a dose of just 2.5 mg/kg |
| treatment in Macular degeneration. In Macular | | | | day--enhanced insulin sensitivity in cells. That low dose |
| degeneration, the aim is not to cure or reverse the | | | | of Resveratrol also reduced insulin resistance in |
| disease but to slow down the free radical damage in | | | | animals fed a high-fat diet, the researchers showed. |
| the retina, which hopefully will prevent further vision | | | | Central nervous system protection by Resveratrol in |
| loss. Certain populations who regularly consume | | | | streptozotocin-induced diabetic rats. |
| anti-oxidant rich foods appear to have lower | | | | Journal of Clinical Neuroscience. 2007 |
| incidences of cancer, diabetes, cardio-vascular | | | | March;14(3):256-60 |
| disease, auto-immune conditions, and many | | | | The aim of this study was to determine the |
| age-related conditions. | | | | protective role of Resveratrol against high blood |
| Chances are you've heard about the French | | | | glucose levels induced in rats by the drug |
| Paradox-you may have even heard about it when | | | | streptozotocin. This drug is used in medical research |
| Barbara Walters did an entire segment concerning the | | | | to produce an animal model for type 1 diabetes. The |
| paradox on 60 Minutes. The "paradox" is the fact | | | | researchers found that the administration of |
| that the French have outstanding heart health, | | | | Resveratrol offered protective action in the brain and |
| despite their consumption of creamy sauces, | | | | spinal cords because it reduced lipid peroxidation and |
| croissants, and pastries, not mention the tremendous | | | | increased glutathione levels. The study concluded that |
| amount of smoking by the French as well. Back in | | | | Resveratrol is a potential neuroprotective agent |
| 1992, scientists put their finger on their secret. The | | | | against diabetic oxidative damage. |
| French drink red wine with nearly every meal, which | | | | Effect of Resveratrol, a polyphenolic phytoalexin, on |
| is rich in a potent 'super-antioxidant,' called | | | | thermal hyperalgesia in a mouse model of diabetic |
| Resveratrol. Resveratrol is a special antioxidant, called | | | | neuropathic pain. |
| a phytoalexin, that's found in the skins and vines of | | | | Fundamental & Clinical Pharmacology. 2007 |
| grapes. Wine grape plants make Resveratrol to | | | | February;21(1):89-94 |
| defend itself from fungal invaders. You can think of it | | | | Pharmacology Division, University Institute of |
| as the plant's natural protective armor, and in many | | | | Pharmaceutical Sciences, Panjab University, |
| ways that's exactly what it does for your body | | | | Chandigarh 160014, India. Diabetic neuropathic pain is |
| when you take it. By helping to scavenge and rid | | | | a symptom associated with diabetes mellitus. This |
| your body of those harmful free radicals, Resveratrol | | | | condition is the result of injury to small blood vessels |
| fights aging and disease. Plus, studies have shown | | | | that supply the nerves. Diabetic neuropathic pain is |
| that Resveratrol helps combat another leading cause | | | | very difficult to treat. The aim of this in vivo study |
| of aging, inflammation. More recent studies are | | | | was to determine the effect of Resveratrol on |
| indicating that Resveratrol has very exciting | | | | diabetic neuropathic pain. The researchers also |
| implications in Diabetes treatments. No wonder 60 | | | | measured the effect of Resveratrol on the serum |
| Minutes-and much of the media-are calling Resveratrol | | | | level of tumor necrosis factor-alpha and whole brain |
| a "fountain of youth" | | | | nitric oxide release. The tests were carried out on |
| The studies on this potent antioxidant are mounting | | | | mice treated with streptozotin to produce an animal |
| fast...o Helps to Protect Your Blood Vessels: | | | | model for Type 1 diabetes. The researchers found |
| Preliminary research suggests that Resveratrol may | | | | that an injection with Resveratrol significantly and |
| help to protect the walls of your blood vessels | | | | dose-dependently attenuated thermal hyperalgesia, |
| against oxidation-which in turn helps to keep your | | | | decreased the serum level of tumor necrosis |
| heart, and entire cardiovascular system healthy.o | | | | factor-alpha and whole brain nitric oxide release. They |
| Keeps Your Blood Flowing as it Should: Preliminary | | | | concluded that Resveratrol holds a potential in |
| studies suggest that the antioxidants in Resveratrol | | | | attenuating diabetic neuropathic pain. |
| may help to inhibit platelet aggregation, helping to | | | | Resveratrol improves insulin secretion from rat |
| keep your blood flowing as it should.o Supports | | | | pancreatic islets. |
| Healthy Blood Pressure: Animal research suggests | | | | European Journal of Pharmacology. 2006 December |
| that the wine polyphenols in Resveratrol support | | | | 15;552(1-3):176-81 |
| healthy blood pressure and healthy blood vessel | | | | The phytochemical Resveratrol is known to have |
| vasodilation-meaning your blood vessels expand and | | | | cardioprotective, anticancer and antioxidant activity |
| relax as they should.o Supports Brain Function: | | | | but resent research also indicates that Resveratrol |
| Preliminary cell and animal research suggests that | | | | may help to alleviate diabetic complications. The aim |
| Resveratrol may support brain function by alleviating | | | | of this study to determine the effect of Resveratrol |
| oxidative stress.o Promotes Optimal Cellular Health: | | | | on insulin secretion from incubated pancreatic islets. |
| The polyphenols in Resveratrol are believed to | | | | The researchers found that Resveratrol increased |
| promote optimal cellular health. Resveratrol may also | | | | the release of insulin after being exposed to glucose. |
| play a role in promoting normal cell division.o Helps | | | | They concluded that Resveratrol exerts reversible |
| Stave off Premature Aging: Resveratrol may play a | | | | effects on insulin secretion from incubated pancreatic |
| role in alleviating oxidative stress and inflammation | | | | islets. |
| that's linked to premature aging.o Promotes Optimal | | | | So what do you do? |
| Dental Health: Preliminary research suggests that | | | | Drink large quantities of red wine? No. The average |
| Resveratrol may help to promote optimal dental | | | | glass of red wine provides a mere 800 mcg of |
| health through its anti-inflammatory properties. | | | | Resveratrol. Therefore, you would need to drink |
| Studies and research abstracts concerning | | | | over 100 glasses per day to reach the threshold |
| Resveratrol and Diabetes | | | | amounts discussed in the scientific studies. The |
| Science Daily (October 2008) - Even relatively low | | | | benefits of Resveratrol are obviously negated by the |
| doses of Resveratrol--a chemical found in the skins | | | | harmful effects of the alcohol ingestion. A better |
| of red grapes and in red wine--can improve the | | | | alternative is to take a supplement containing |
| sensitivity of mice to the hormone insulin, according | | | | Resveratrol. Several studies indicate that if the wrong |
| to a new report. As insulin resistance is often | | | | form of Resveratrol is used, it may not be biologically |
| characterized as the most critical factor contributing | | | | effective. In addition, pills, tablets, and capsules of |
| to the development of type 2 diabetes, the findings | | | | Resveratrol are less effective than ingesting a liquid |
| "provide a potential new therapeutic approach for | | | | form of Resveratrol. So what are you going to do? |
| preventing or treating" both conditions, the | | | | Consider drinking MonaVie Pulse! |
| researchers said. The research group also confirmed | | | | MonaVie PULSE is a nutritional beverage that contains |
| that increased levels of an enzyme called SIRT1, | | | | 19 fruits including Acai berry, Prickly pear, Bilberry, |
| which earlier studies had linked to longevity, DNA | | | | Apple, Aronia berry, Cranberry, Pineapple, Raspberry, |
| repair, and insulin secretion, improve insulin sensitivity | | | | Elderberry, Pomegranate, Tart cherry, Cupuacu, |
| in mice. Resveratrol is known to activate the SIRT1 | | | | Blueberry, Strawberry, Acerola cherry, Yum berry, |
| enzyme. | | | | Camu-Camu, Concord grape, and Blackberry. This |
| The results suggest that "red wine might have some | | | | formula contains plant sterols in such concentration to |
| benefits for insulin sensitivity, but given the potential | | | | deliver a therapeutic dose which has found to be |
| complications of drinking alcohol, an even better | | | | effective in reducing cholesterol by the FDA and |
| option may be to find other natural foods enriched | | | | MonaVie has been approved as an alternative |
| with Resveratrol or foods supplemented with | | | | treatment for lowering cholesterol levels. Multiple |
| Resveratrol," he added. | | | | studies have shown that ingesting 0.8 grams of plant |
| Diabetes mellitus, the most common endocrine | | | | sterols per day is effective in lowering cholesterol |
| disorder, currently affects more than 170 million | | | | 8-15%. Two studies recommend adding plant sterols |
| people worldwide and is expected to affect more | | | | to one's diet rather than adding additional statin drugs |
| than 353 million by the year 2030, Zhai said. Type 2 | | | | to achieve lower cholesterol levels. One study |
| diabetes, which accounts for more than 90 percent | | | | indicated that there were significantly less side |
| of diabetes cases, is characterized by the resistance | | | | effects when using plant sterols as the first line |
| of body tissues to stimulation by the peptide | | | | treatment modality in fighting high cholesterol levels. |
| hormone insulin. Insulin normally lowers blood glucose | | | | In additional to the cholesterol lowering ability offered |
| levels by facilitating the sugar's uptake, mainly into | | | | by MonaVie Pulse, when Resveratrol is added into |
| skeletal muscle and fat tissue, and by inhibiting | | | | the formula, MonaVie Pulse has the added benefit of |
| glucose production in the liver. Currently, alleviating | | | | cardio-protection, reduced hypertension, improved |
| insulin resistance is still one of the key avenues to | | | | HDL levels, and decreased insulin insensitivity. |
| treating type 2 diabetes. | | | | As quoted in the study abstracts listed above, |
| Earlier studies had reported a connection between | | | | Resveratrol offers Type II diabetics unprecedented |
| SIRT1 and the processes of glucose metabolism and | | | | natural treatment options. The Resveratrol contained |
| insulin secretion. However, whether SIRT1 was | | | | in MonaVie Pulse is a purified, clinically relevant, |
| directly involved in insulin sensitivity remained largely | | | | concentrated amount in liquid form. This liquid |
| unknown, the researchers said. Now, the researchers | | | | Resveratrol is better tolerated and absorbed by |
| report that SIRT1 levels are reduced in | | | | most people. Anechtdotal studies indicate that many |
| insulin-resistant cells and tissues and that treatments | | | | diabetics have reduced their medications and |
| that block the enzyme's function lead to insulin | | | | treatments after using MonaVie Pulse on a consistent |
| resistance. Furthermore, increased SIRT1 activity | | | | and regular basis. |
| improved insulin sensitivity. Similarly, Resveratrol--at a | | | | MonaVie does NOT recommend deviating from |
| dose of just 2.5 mg/kg/day--enhanced insulin | | | | current treatments without professional, medical |
| sensitivity in cells. That low dose of Resveratrol also | | | | advice, instruction, and direction.MonaVie does NOT |
| reduced insulin resistance in animals fed a high-fat | | | | recommend or portray any of their products as a |
| diet, the researchers showed. Resveratrol is known | | | | treatment, cure, drug, or medication. MonaVie |
| to activate a gene called SIRT1, and SIRT1 is linked | | | | products are nutritional beverages that incorporate 19 |
| not only to insulin secretion, but also to better insulin | | | | super fruits into a healthy blend of juice. Results will |
| sensitivity in mice. Other research has found a | | | | vary from person to person. Please do not |
| connection between SIRT1 and glucose metabolism. | | | | discontinue medications and/ or treatments without |
| Researchers have reported that insulin resistant | | | | first seeking medical evaluation and expert medical |
| disorders like diabetes block normal activation of | | | | advice. |
| SIRT1, a factor resulting in the active study of SIRT1 | | | | |