| Glycogen storage diseases (GSD) comprises of a | | | | manifestations and complications include |
| series of rare genetic disorders of glycogen metabolic | | | | hepatomegaly, hypoglycaemia, hyperlactatemia, |
| processes and the enzymatic system. Therefore, | | | | hyperuricemia and hyperlipaemia (high levels of |
| glycogen cannot be metabolized to glucose in the | | | | cholesterol). |
| liver. GSDs are characterised by abnormally inherited | | | | Type II is a paradigm of inborn lysosomal storage |
| glycogen metabolism in the liver, muscle, and brain. | | | | diseases and affects several organs but mainly the |
| Various endocrines (hormones), such as insulin, | | | | musculus. |
| glucagon, and hydrocortisone influence the relationship | | | | Type IIIa affects both the liver and muscle, and IIIb |
| of glycolysis (Glycolysis is the set of reactions that | | | | exclusively the liver. The liver symptoms commonly |
| converts glucose into energy), gluconeogenesis (the | | | | improve with with gowth. |
| synthesis glucose, from carbon substrates such as | | | | Type IV generally exhibits in the 1st year of lifespan, |
| pyruvate, lactate, glycerol, and glucogenic amino | | | | with megalohepatia and development and mental |
| acids) and glycogen synthesis. | | | | retardation. The disease in at-large is advancing |
| The general GSD occurrences are estimated at | | | | leading to cirrhosis of the liver. |
| something like 1 case per 0000 babies. Currently | | | | Type VI and IX are a heterogenous group of |
| there are about a dozen subtypes and they are | | | | diseases stimulated by a lack of the liver |
| categorised based on the enzyme insufficiency and | | | | phosphorylase and phosphorylase kinase system. |
| the involved organs. Disorders of glycogen | | | | There is no hyperuricemia or hyperlactatemia. |
| degradation or Hers Disease could strike mainly the | | | | Type XI is mainly characterised by hepatic |
| liver, the muscles and/or both. | | | | glycogenosis and renal Fanconi syndrome. |
| Type Ia affects the liver, kidney and the intestine | | | | Types V and VII involve only the muscle. |
| while Ib effects the leukocytes. Some clinical | | | | |