| Resveratrol is a phytoalexin (anti-fungal and | | | | benzo[a]pyrene. J. Appl. Toxicol. 2003;23:255-61). |
| anti-bacterial chemical) produced naturally by grapes | | | | Heart Disease |
| and other plants in response to fungal infection. | | | | Research of Resveratrol and its effects on the heart |
| Found abundantly in the skin of red grapes, | | | | have reported Resveratrol to have extensive |
| Resveratrol shows promising results in combating | | | | potential benefits: As a potentially potent antioxidant |
| diseases like cancer, cardiovascular and related heart | | | | activity. Resveratrol is a powerful antioxidant. It helps |
| disease, and Alzheimer's disease. Research also looks | | | | prevent lipid peroxidation of low-density lipoprotein. A |
| promising for its role in extending life span, promoting | | | | study published in Free Radical Research reported |
| anti-viral activity and increasing physical stamina.It is | | | | that testing of Resveratrol, Vitamin E and a synthetic |
| important to note that research on Resveratrol has | | | | antioxidant resulted in resveratrol as the best |
| been done only in test tubes or rodents. While | | | | defense against scavenging artery-damaging radicals. |
| evidence is still inconclusive, the volume of research | | | | (Ref. Tadolini, B. et al. Resveratrol inhibition of lipid |
| and positive inferences suggest that Resveratrol | | | | peroxidation. Free Radic. Res. 2000;33:105-14) |
| could have massive, revolutionary possibilities for | | | | In helping prevent damage to blood vessels. A recent |
| treating human beings! | | | | British research claims Resveratrol protects against |
| Longevity | | | | cellular damage to blood vessels caused by high |
| Resveratrol became the first-ever supplement known | | | | production of glucose in diabetes. These elevated |
| to activate a longevity gene. Aging and death is | | | | levels of glucose can cause heart disease, kidney |
| caused by older cells losing their ability to perfectly | | | | disease, and blindness. Dr. Matt Whiteman, lead |
| replicate DNA, producing DNA "mistakes". DNA | | | | researcher, stated, "...our research shows the link |
| mistakes accumulate forming "DNA debris" which | | | | between high levels of glucose, its damaging effect |
| eventually stops a cell from functioning. Studies show | | | | on cell structure, and the ability of resveratrol to |
| that Resveratrol reduces the frequency of "DNA | | | | protect against and mend that damage." |
| debris" by 60% through the longevity gene that it | | | | In helping reduce cholesterol. Resveratrol has been |
| stimulates. | | | | shown to modulate the metabolism of lipids, and |
| (Ref. Hall, S.S., 2003. Longevity research. In vino | | | | inhibit the oxidation of low-density lipoproteins, thus |
| vitalis? Compounds activate life-extending genes. | | | | helping to regulate cholesterol levels. |
| Science 301, 1165). | | | | In helping protect the blood circulation and heart |
| Cancer | | | | function. Nitric oxide, a major component in heart |
| Study of Resveratrol done at the University of | | | | artery function allows blood vessels to "relax," thus |
| Rochester shows mounting evidence that suggests | | | | enhancing blood flow. A diet high in cholesterol has |
| Resveratrol kills cancer cells while protecting healthy | | | | been found to decrease the function of nitric oxide |
| cells from radiation treatment. It does this by disabling | | | | by about one third. Research found Resveratrol |
| the cancer cell's mitochondria (DNA power source). | | | | supplements significantly reversed this trend, helping |
| Dr. Paul Okunieff, lead author of this research | | | | protect blood circulation and heart function. |
| announced, "Resveratrol seems to have a therapeutic | | | | (Ref .Zou JG, et al. Effect of red wine and wine |
| gain by making tumor cells more sensitive to radiation | | | | polyphenol resveratrol on endothelial function in |
| and making normal tissue less sensitive". He further | | | | hypercholesterolemic rabbits. Int. J. Mol. Med. |
| stated, "this research indicates that resveratrol has a | | | | 2003;11:317-20). |
| promising future as part of the treatment for | | | | In helping prevent platelet aggregation which leads to |
| cancer." | | | | blood clots, heart attacks and strokes. Resveratrol |
| (Ref. Mounting Evidence Shows Red Wine Antioxidant | | | | keeps blood cells from sticking together. Canadian |
| Kills Cancer", Department of Radiation Oncology, | | | | researchers found that nothing else they tested was |
| University of Rochester Medical Center., 2008-03-26. | | | | active against this aspect of heart disease except |
| Retrieved on 2008-03-26). | | | | Resveratrol, which inhibited not only thrombin, but a |
| Atheltic Performance | | | | host of other stickiness-promoting factors. |
| Mice that were fed resveratrol for 15 weeks showed | | | | (Ref. Pace-Asciak, C.R. et al. The red wine phenolics |
| better treadmill endurance. The study supported a | | | | trans-resveratrol and quercetin block human platelet |
| hypothesis that the effects of resveratrol are due to | | | | aggregation and eicosanoid synthesis: implications for |
| the activation of SIRT1. | | | | protection against coronary heart disease. Clin. Chim. |
| (Ref. Johan Auwerx, Institute of Genetics and | | | | Acta. 1995;235:207-19).Sources of Resveratrol |
| Molecular and Cell Biology in Illkirch, France). | | | | Foods containing resveratrol are red wine, peanuts, |
| Antiviral Effects | | | | cranberries, blueberries, Japanese knotweed.The |
| The study of Resveratrol has shown promising | | | | concentration of Resveratrol in red wine varies from |
| results, in vitro, in increasing the potency of some | | | | wine to wine. Excess consumption of wine can also |
| anti-retro-viral drugs against HIV. Study also showed | | | | be harmful to health, and addictive. The best way to |
| 90% effectiveness when resveratrol was added six | | | | obtain a standardized amount of Resveratrol daily is |
| hours after an influenza virus infection. | | | | to take a Resveratrol supplement. Trans-resveratrol |
| (Ref. Revel, A. et al. Resveratrol, a natural aryl | | | | in the powder form is used in making Resveratrol |
| hydrocarbon receptor antagonist, protects lung from | | | | supplements, like Red Defense. This is also a good |
| DNA damage and apoptosis caused by | | | | option for people who do not consume alcohol. |