Whose Got Kidney Stones - Gender, Genetics and Geography

Each year between 600,000 and 1,000,000closing with an increase in the number of women
Americans will be affected by kidney stones. It hasgetting them. This may be in part due the diets of
been estimated that 20% of the time it will requirewomen becoming more similar. Also a women's
hospitalization. For unknown reasons, the number ofanatomy is set up to produce more UTIs than in
people affected by them has been on the increasemen and the combination of a kidney stone and
over the past 20 years, especially in developedinfection makes for a less positive outcome.
nations. Even though the prevalence of kidney stonesGenetics
is on the rise, stones have been found in an EgyptianOverall, stone formation is 4-5 times more likely in
skeleton estimated to be over 7000 years old. ManyCaucasians than in African Americans with calcium
notable individuals have suffered from them, includingstones more likely in those with Anglo-Saxon
Louis Napolean III (Emperor of France), Benjaminancestries. Uric Acid stones form more commonly in
Franklin, and Lyndon B Johnson.those of Mediterranean ancestries, particularly those
Seventy-Five percent of stone suffers will have atof Portuguese extraction. It is not fully understood
least one recurrence. The relative risk of forming awhy certain stones run in families or common
second stone in 10 years 60-80%, in 5 years 50 %;ancestries. It may be due to inherited physiological
two-thirds of men experience recurrent with anfactors or result of shared family dietary preferences
average of 9 years between episodes. After 20Geography
years, less than 10% remain stone free. AnThe peak season of kidney stone formation seems
unfortunate 10-15 % portion of patients will haveto coincide with the summer months of June through
aggressive disease with the formation of 10+ stonesAugust. This is not that hard to understand when
over their lifetime.one thinks about the role that water plays in keeping
Genderthe body producing urine that is not concentrated
Men suffer from stone formation four times moreand the increase activity one has during the summer.
often than women. Men may tend to produce moreHere in the United States, the Southeast has the
stones because they eat more than women includinghighest incidence of stones. Increased temperature
diets that are not healthy and being larger, produceand body hydration may be key factors. The
more metabolic wastes than women. In the past fewsouthern diet of green vegetables, brewed tea and
years, there has been a trend where the ratio isfatty foods may also be contributing factors.